Consistent with an anticancer function for complement and a countermeasure to its action, tumors often have higher expression of complement-regulatory proteins such as CD46, CD55 and CD59. These ...

“The whole is greater than the sum of its parts.” — Aristotle Figure 1: Complement-mediated intracellular and autocrine regulation of the activation of CD4 + T cells. The studies noted above have ...

Alzheimer's disease (AD) is a common cause of dementia. Serum complement factor 5a (C5a) is exceedingly implicated in AD. We explored the role of C5a levels in AD patients of different severity. Serum ...

Introduction: To date, oncology patients are more dependent on non-cellular host defense against pathogens due to intensive (chemo)therapy-related bone marrow suppression. Since data on complement ...

The innate immune response is evolutionary conserved among organisms. The complement system forms an important and efficient immune defense mechanism. It consists of plasma proteins that participate ...

Complement molecules are the immune proteins responsible for identifying bacteria, viruses, and other foreign invaders as they circulate through our bodies. Their function helps lymphocytes to locate ...

Traumatic brain injury (TBI) is a major cause of disability and a risk factor for early-onset dementia. The injury is characterized by a physical insult followed acutely by complement driven ...

Hemolytic uremic syndrome caused by an invasive Streptococcus pneumoniae infection (SP-HUS) is a rare and severe disease that primarily affects children under two years of age. The pathophysiology of ...