To further the quantitative understanding of cellular decision making, Dr. Gregory Reeves and his team in the chemical engineering department have worked to interpret how a transcription factor ...

Plant breeding has contributed to the sustainability of crop production since antiquity and is expected to play an increasingly important role in the ...

Researchers developed e2MPRA, a high-throughput technique that simultaneously measures cis-regulatory element activity and epigenetic state. By analyzing thousands of sequences, the method showed that ...

DNA is the blueprint of life. Genes encode proteins and serve as the body's basic components. However, building a functioning ...

A massive genomics effort has identified thousands of single nucleotide non-coding variants, which alter gene activity, that link to disease and health.

Gene regulation is far more predictable than previously believed, scientists conclude after developing deep learning model PARM. This might bring an end to a scientific mystery: how genes know when to ...

A new artificial intelligence-driven pipeline developed in a collaborative research combines protein structure prediction, sequence design, and live-cell screening together to enable rapid conversion ...

Researchers led by Min Zhang and Dabao Zhang of the University of California, Irvine's Joe C. Wen School of Population & Public Health have created the most detailed maps to date showing how genes ...

Less than 2% of the genome codes for proteins; the rest, once called 'junk DNA', contains regulatory elements. Researchers analyzed 10,000 to reveal how variants shape gene activity.

Inside every cell, thousands of molecular signals collide, overlap, and compensate, obscuring the true drivers of gene expression. Scientists have now developed a way to silence that cellular noise, ...