Targeted protein degradation (TPD) approaches including PROTAC and molecular glue have revolutionized drug discovery. However, in part due to complication of the ubiquitination and related ...

Cells organize their molecules in distinct functional areas. While textbooks usually refer to membrane-bound organelles such as mitochondria and cell nuclei, recent studies have also revealed ...

Researchers from IOCB Prague are furthering the understanding of how medicines work and what it takes to develop their most effective variants. In one current study, they have focused on the disease ...