－実験室での生命誕生過程の再現に向けて－ 理化学研究所（理研）生命機能科学研究センター高機能生体分子開発チームの李佩瑩（リ・ペエイ）研究員、田上俊輔チームリーダーらの国際共同研究チームは、正電荷を持つペプチド[1] 凝集体がRNA[2] を吸着し ...

From vaccines and diagnostics to emerging gene-based therapies, RNA molecules are now central to modern medicine. But as ...

2024年のノーベル生理学・医学賞を受賞したビクター・アンブロス博士とゲイリー・ラブカン博士が発見したのがマイクロRNAです。マイクロRNAは遺伝子制御を担う分子として、現在ヒトには2,000種類以上あることがわかっており、マイクロRNAの異常は疾患と ...

A proposed function of TADs is to contribute to gene regulation by promoting chromatin interactions within a TAD and by suppressing interactions between TADs. Here, we directly probe the ...

Inside every cell, thousands of molecular signals collide, overlap, and compensate, obscuring the true drivers of gene expression. Scientists have now developed a way to silence that cellular noise, ...

With big pharma signalling interest in novel RNA-targeted approaches, the term “druggable” is being redefined as technology advances.

Researchers developed C28, an engineered polymerase that efficiently synthesizes RNA at near-natural speeds with high accuracy. Created through directed evolution, the enzyme also performs reverse ...

By Hugo Francisco de Souza Emerging research suggests reversible RNA editing mechanisms may influence heart disease biology while opening new avenues for biomarkers and next-generation cardiovascular ...

AI can help protein engineers optimize the transcription enzymes used to make mRNA-based vaccines and therapeutics, say the authors of a new study.