A cancer drug class best known for attacking tumors may also help your immune system remember them better. Researchers at ...

Reprogramming the human genome toward any desirable state is within reach; application of select transcription factors drives cell types toward different lineages in many settings. We introduce the ...

Gastric cancer (GC) remains a significant global health concern due to its poor prognosis and limited therapeutic options, particularly in advanced stages. Tumor microenvironment (TME), particularly ...

Data that has been accumulated over many years regarding the mechanisms of cell differentiation has enabled the development of cell reprogramming – a brand new strategy in biotechnology. The ability ...

Outside the neurogenic niches, the adult brain lacks multipotent progenitor cells. In this study, we performed a series of in vivo screens and reveal that a single factor can induce resident brain ...

LISBON, March 5 (Xinhua) -- Scientists have successfully created anti-tumor immune cells in a laboratory using cellular reprogramming for the first time, opening new possibilities in the fight against ...

Pluripotent stem cells can differentiate into nearly all types of cells in the body. This unique potential provides significant promise for cell-based therapies to restore tissues or organs destroyed ...

The adult heart is one of the least regenerative tissues in the human body. After hypoxemia from myocardial infarction (MI), cardiomyocytes undergo massive cell death, and resident cardiac fibroblasts ...

Reprogramming of the cochlea with hair-cell-specific transcription factors such as ATOH1 has been proposed as a potential therapeutic strategy for hearing loss. ATOH1 expression in the developing ...

The capacity of an organism to regenerate depends on cell dedifferentiation followed by proliferation. Mammals, in general, have limited regenerative capacity. Now, a team of researchers at the Salk ...