You are free to share (copy and redistribute) this article in any medium or format and to adapt (remix, transform, and build upon) the material for any purpose, even commercially within the parameters ...

Topoisomerases are a family of proteins that alter DNA topology to accommodate for the stresses imparted by processes such as transcription, replication, and mitotic chromosome condensation.

Figure 1: General features of type IIA and IIB topoisomerases. To address these and other outstanding issues, we have determined the structure of a full-length type II topoisomerase, Methanosarcina ...

Wessel, I ∙ Jensen, PB ∙ Falck, J ∙ et al. Loss of amino acids 1490Lys-Ser-Lys1492 in the COOH-terminal region of topoisomerase IIin human small cell lung cancer cells selected for resistance to ...

In the eukaryotic genome, DNA associates with proteins and forms two main types of chromatin, the highly condensed heterochromatin, which is inaccessible to transcription factors and hence ...

Topoisomerase I and II are normal host enzymes that are found in the nucleus of mammalian cells and are required for normal DNA replication and cellular division. The enzymes create and then repair ...

Topoisomerase V is a unique topoisomerase that combines DNA repair and topoisomerase activities. The enzyme has an unusual arrangement, with a small topoisomerase domain followed by 12 tandem (HhH) 2 ...

Irinotecan and topotecan have been widely used as anticancer drugs for the past 20 years. Because of their selectivity as topoisomerase I (TOP1) inhibitors that trap TOP1 cleavage complexes, ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator.

Background: Systemic sclerosis (SSc) is an autoimmune disease characterised by the production of autoantibodies, which leads to fibrosis and finally damage to various tissues and organs. Recent ...

A topoisomerase enzyme discovered more than a decade ago in an archaeal microorganism turns out to be distinct, both structurally and mechanistically, from any other known topoisomerase. Only four ...